Transplantation of a healthy pancreas is a treatment for individuals with insulin-dependent diabetes. Pancreas transplantation can restore glucose control and prevent, halt, or reverse the secondary complications from diabetes.
Pancreas transplant after a prior kidney transplant may be considered medically necessary in individuals with insulin-dependent diabetes.
A combined pancreas and kidney transplant may be considered medically necessary in insulin-dependent diabetic individuals with uremia.
Pancreas transplant alone may be considered medically necessary in individuals with severely disabling and potentially life-threatening complications due to hypoglycemia unawareness and labile insulin-dependent diabetes that persists despite optimal medical management.
Pancreas re-transplant after a failed primary pancreas transplant may be considered medically necessary in patients who meet criteria for pancreas transplantation.
Pancreas transplant not meeting the criteria as indicated in this policy is considered not medically necessary.
In addition to the above criteria and subject to the discretion of the transplant center, a Hepatitis C Virus (HCV) positive donor organ maybe considered an acceptable organ option for an HCV negative adult recipient 18 years of age or older.
48550 |
48551 |
48552 |
48554 |
48556 |
48999 |
50300 |
50320 |
50323 |
50325 |
50327 |
50328 |
50329 |
50340 |
50360 |
50365 |
50370 |
50380 |
50547 |
S2065 |
|
General Criteria
Potential contraindications for solid organ transplant that are subject to the judgment of the transplant center include the following:
Pancreas-Specific Criteria
Candidates for pancreas transplant alone should also meet one of the following severity of illness criteria:
Additionally, most pancreas transplant patients will have type 1 diabetes. Those transplant candidates with type 2 diabetes, in addition to being insulin-dependent, should also not be obese (body mass index should be ≤32 kg/m2).
Multiple Transplant Criteria
Although there are no standard guidelines for multiple pancreas transplants, the following information may aid in case review:
See Medical Policy E-42, Continuous Glucose Monitors (CGM), for additional information.
See Medical Policy S-124, Kidney Transplant, for additional information.
Organ Procurement and Transplantation Network-2022
The Organ Procurement and Transplantation Network updated its comprehensive list of transplant-related policies, most recently in September 2022.
For pancreas registration:
“Each candidate registered on the pancreas waiting list must meet one of the following requirements:
The American Society of Transplantation-2017
The American Society of Transplantation (2017) convened a consensus conference of experts to address issues related to the transplantation of hepatitis C virus (HCV) non-viremic recipients. Key findings and recommendations are:
Covered Diagnosis Codes for Procedure Codes 48550, 48551, 48552, 48554, 48999, S2065
E10.8 |
E10.10 |
E10.11 |
E10.21 |
E10.22 |
E10.29 |
E10.36 |
E10.39 |
E10.40 |
E10.41 |
E10.42 |
E10.43 |
E10.44 |
E10.49 |
E10.51 |
E10.52 |
E10.59 |
E10.65 |
E10.69 |
E10.311 |
E10.319 |
E10.610 |
E10.618 |
E10.620 |
E10.621 |
E10.622 |
E10.628 |
E10.630 |
E10.638 |
E10.641 |
E10.649 |
E10.3211 |
E10.3212 |
E10.3213 |
E10.3291 |
E10.3292 |
E10.3293 |
E10.3311 |
E10.3312 |
E10.3313 |
E10.3391 |
E10.3392 |
E10.3393 |
E10.3411 |
E10.3412 |
E10.3413 |
E10.3491 |
E10.3492 |
E10.3493 |
E10.3511 |
E10.3512 |
E10.3513 |
E10.3591 |
E10.3592 |
E10.3593 |
E11.8 |
E11.00 |
E11.01 |
E11.10 |
E11.11 |
E11.21 |
E11.22 |
E11.29 |
E11.36 |
E11.39 |
E11.40 |
E11.41 |
E11.42 |
E11.43 |
E11.44 |
E11.49 |
E11.51 |
E11.52 |
E11.59 |
E11.65 |
E11.69 |
E11.311 |
E11.319 |
E11.610 |
E11.618 |
E11.620 |
E11.621 |
E11.622 |
E11.628 |
E11.630 |
E11.638 |
E11.641 |
E11.649 |
E11.3211 |
E11.3212 |
E11.3213 |
E11.3291 |
E11.3292 |
E11.3293 |
E11.3311 |
E11.3312 |
E11.3313 |
E11.3391 |
E11.3392 |
E11.3393 |
E11.3411 |
E11.3412 |
E11.3413 |
E11.3491 |
E11.3492 |
E11.3493 |
E11.3511 |
E11.3512 |
E11.3513 |
E11.3591 |
E11.3592 |
E11.3593 |
E13.8 |
E13.21 |
E13.22 |
E13.29 |
E13.69 |
T86.890 |
T86.891 |
T86.892 |
T86.898 |
T86.899 |
Z79.4 |
Z90.5 |
|
|
Covered Diagnosis Codes for Procedure Codes: 50300, 50320, 50323, 50325, 50327, 50328, 50329, 50340, 50360, 50365, 50370, 50380, 50547
N18.4 |
N18.5 |
N18.6 |
N18.9 |
|
|
|
This policy is designed to address medical guidelines that are appropriate for the majority of individuals with a particular disease, illness, or condition. Each person's unique clinical or other circumstances may warrant individual consideration, based on review of applicable medical records, as well as other regulatory, contractual and/or legal requirements.
Medical policies do not constitute medical advice, nor are they intended to govern the practice of medicine. They are intended to reflect Highmark's reimbursement and coverage guidelines. Coverage for services may vary for individual members, based on the terms of the benefit contract.
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Discrimination is Against the Law
The Claims Administrator/Insurer complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. The Claims Administrator/Insurer does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. The Claims Administrator/ Insurer:
If you need these services, contact the Civil Rights Coordinator.
If you believe that the Claims Administrator/Insurer has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: Civil Rights Coordinator, P.O. Box 22492, Pittsburgh, PA 15222, Phone: 1-866-286-8295, TTY: 711, Fax: 412-544-2475
, email: CivilRightsCoordinator@highmarkhealth.org. You can file a grievance in person or by mail, fax, or email. If you need help filing a grievance, the Civil Rights Coordinator is available to help you.
You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf, or by mail or phone at:
U.S. Department of Health and Human Services
200 Independence Avenue, SW
Room 509F, HHH Building
Washington, D.C. 20201
1-800-368-1019, 800-537-7697
(TDD)
Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html.
This information is issued by Highmark Blue Shield on behalf of its affiliated Blue companies, which are independent licensees of the Blue Cross Blue Shield Association. Highmark Inc. d/b/a Highmark Blue Shield and certain of its affiliated Blue companies serve Blue Shield members in the 21 counties of central Pennsylvania. As a partner in joint operating agreements, Highmark Blue Shield also provides services in conjunction with a separate health plan in southeastern Pennsylvania. Highmark Inc. or certain of its affiliated Blue companies also serve Blue Cross Blue Shield members in 29 counties in western Pennsylvania, 13 counties in northeastern Pennsylvania, the state of West Virginia plus Washington County, Ohio, the state of Delaware[ and [8] counties in western New York and Blue Shield members in [13] counties in northeastern New York]. All references to Highmark in this document are references to Highmark Inc. d/b/a Highmark Blue Shield and/or to one or more of its affiliated Blue companies.
Medical policies do not constitute medical advice, nor are they intended to govern the practice of medicine. They are intended to reflect reimbursement and coverage guidelines. Coverage for services may vary for individual members, based on the terms of the benefit contract.
Discrimination is Against the Law
The Claims Administrator/Insurer complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. The Claims Administrator/Insurer does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. The Claims Administrator/ Insurer:
If you believe that the Claims Administrator/Insurer has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: Civil Rights Coordinator, P.O. Box 22492, Pittsburgh, PA 15222, Phone: 1-866-286-8295, TTY: 711, Fax: 412-544-2475, email: CivilRightsCoordinator@highmarkhealth.org. You can file a grievance in person or by mail, fax, or email. If you need help filing a grievance, the Civil Rights Coordinator is available to help you.
You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf, or by mail or phone at:
U.S. Department of Health and Human Services
200 Independence Avenue, SW
Room 509F, HHH Building
Washington, D.C. 20201
1-800-368-1019, 800-537-7697 (TDD)
Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html.