A variety of growth factors have been found to play a role in wound healing, including platelet-derived growth factors (PDGF), epidermal growth factor, fibroblast growth factors, transforming growth factors, and insulin-like growth factors. Autologous platelets are a rich source of PDGF, transforming growth factors (that function as a mitogen for fibroblasts, smooth muscle cells, and osteoblasts), and vascular endothelial growth factors.
Autologous platelet concentrate suspended in plasma, also known as platelet-rich plasma (PRP), can be prepared from samples of centrifuged autologous blood. PRP is distinguished from fibrin glues or sealants.
Recombinant platelet-derived growth factor (i.e., becaplermin [Regranex]) may be considered medically necessary when used as an adjunct to standard wound management when EITHER of the following criteria has been met:
Becaplermin gel for treatment of neuropathic ulcers may be considered medically necessary when ALL of the following criteria are met:
Becaplermin gel for the treatment of pressure ulcers may be considered medically necessary when ALL of the following criteria are met:
All other applications of recombinant platelet-derived growth factor (i.e., becaplermin [Regranex]) are considered experimental/investigational, and therefore, non-covered including, but not limited to, ischemic ulcers, ulcers related to venous stasis, and ulcers not extending through the dermis into the subcutaneous tissue. The safety and/or effectiveness cannot be established by review of the published peer-reviewed literature.
S0157 |
S9055 |
|
|
|
|
|
Use of autologous blood-derived preparations (i.e., injection of PRP) is considered experimental/investigational and therefore non-covered for ALL non-orthopedic conditions because the effectiveness cannot be established by published peer-reviewed literature.
0232T |
0481T |
86999 |
G0460 |
P9020 |
|
|
Refer to Medical Policy S-265, Orthopedic Applications of Platelet-Rich Plasma, for additional information.
Refer to Medical Policy S-244, Fibrin Sealants, for additional information.
Covered Diagnosis Codes for Procedure Codes: S0157, S9055, 86999
E08.621 |
E08.622 |
E09.621 |
E09.622 |
E10.21 |
E10.40 |
E10.41 |
E10.42 |
E10.43 |
E10.49 |
E10.621 |
E10.622 |
E11.40 |
E11.41 |
E11.42 |
E11.43 |
E11.49 |
E11.621 |
E11.622 |
E13.621 |
E13.622 |
L89.43 |
L89.44 |
L89.93 |
L89.94 |
L89.003 |
L89.004 |
L89.013 |
L89.014 |
L89.023 |
L89.024 |
L89.103 |
L89.104 |
L89.113 |
L89.114 |
L89.123 |
L89.124 |
L89.133 |
L89.134 |
L89.143 |
L89.144 |
L89.153 |
L89.154 |
L89.203 |
L89.204 |
L89.213 |
L89.214 |
L89.223 |
L89.224 |
L89.303 |
L89.304 |
L89.313 |
L89.314 |
L89.323 |
L89.324 |
L89.503 |
L89.504 |
L89.513 |
L89.514 |
L89.523 |
L89.524 |
L89.603 |
L89.604 |
L89.613 |
L89.614 |
L89.623 |
L89.624 |
L89.813 |
L89.814 |
L89.893 |
L89.894 |
L89.94 |
L97.102 |
L97.103 |
L97.104 |
L97.105 |
L97.106 |
L97.108 |
L97.112 |
L97.113 |
L97.114 |
L97.115 |
L97.116 |
L97.118 |
L97.122 |
L97.123 |
L97.124 |
L97.125 |
L97.126 |
L97.128 |
L97.202 |
L97.203 |
L97.204 |
L97.205 |
L97.206 |
L97.208 |
L97.212 |
L97.213 |
L97.214 |
L97.215 |
L97.216 |
L97.218 |
L97.222 |
L97.223 |
L97.224 |
L97.225 |
L97.226 |
L97.228 |
L97.302 |
L97.303 |
L97.304 |
L97.305 |
L97.306 |
L97.308 |
L97.312 |
L97.313 |
L97.314 |
L97.315 |
L97.316 |
L97.318 |
L97.322 |
L97.323 |
L97.324 |
L97.325 |
L97.326 |
L97.328 |
L97.402 |
L97.403 |
L97.404 |
L97.405 |
L97.406 |
L97.408 |
L97.412 |
L97.413 |
L97.414 |
L97.415 |
L97.416 |
L97.418 |
L97.422 |
L97.423 |
L97.424 |
L97.425 |
L97.426 |
L97.428 |
L97.502 |
L97.503 |
L97.504 |
L97.505 |
L97.506 |
L97.508 |
L97.512 |
L97.513 |
L97.514 |
L97.515 |
L97.516 |
L97.518 |
L97.522 |
L97.523 |
L97.524 |
L97.525 |
L97.526 |
L97.528 |
L97.802 |
L97.803 |
L97.804 |
L97.805 |
L97.806 |
L97.808 |
L97.812 |
L97.813 |
L97.814 |
L97.815 |
L97.816 |
L97.818 |
L97.822 |
L97.823 |
L97.824 |
L97.825 |
L97.826 |
L97.828 |
L97.902 |
L97.903 |
L97.904 |
L97.905 |
L97.906 |
L97.908 |
L97.912 |
L97.913 |
L97.914 |
L97.915 |
L97.916 |
L97.918 |
L97.922 |
L97.923 |
L97.924 |
L97.925 |
L97.926 |
L97.928 |
L98.412 |
L98.413 |
L98.414 |
L98.415 |
L98.416 |
L98.418 |
L98.422 |
L98.423 |
L98.424 |
L98.425 |
L98.426 |
L98.428 |
L98.492 |
L98.493 |
L98.494 |
L98.495 |
L98.496 |
L98.498 |
|
This policy is designed to address medical guidelines that are appropriate for the majority of individuals with a particular disease, illness, or condition. Each person's unique clinical or other circumstances may warrant individual consideration, based on review of applicable medical records, as well as other regulatory, contractual and/or legal requirements.
Medical policies do not constitute medical advice, nor are they intended to govern the practice of medicine. They are intended to reflect Highmark's reimbursement and coverage guidelines. Coverage for services may vary for individual members, based on the terms of the benefit contract, and subject to the applicable laws of your state.
Highmark retains the right to review and update its medical policy guidelines at its sole discretion. These guidelines are the proprietary information of Highmark. Any sale, copying or dissemination of the medical policies is prohibited; however, limited copying of medical policies is permitted for individual use.
Discrimination is Against the Law
The Claims Administrator/Insurer complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. The Claims Administrator/Insurer does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. The Claims Administrator/ Insurer:
If you need these services, contact the Civil Rights Coordinator.
If you believe that the Claims Administrator/Insurer has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: Civil Rights Coordinator, P.O. Box 22492, Pittsburgh, PA 15222, Phone: 1-866-286-8295, TTY: 711, Fax: 412-544-2475, email: CivilRightsCoordinator@highmarkhealth.org. You can file a grievance in person or by mail, fax, or email. If you need help filing a grievance, the Civil Rights Coordinator is available to help you.
You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf, or by mail or phone at:
U.S. Department of Health and Human Services
200 Independence Avenue, SW
Room 509F, HHH Building
Washington, D.C. 20201
1-800-368-1019, 800-537-7697 (TDD)
Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html.
Insurance or benefit/claims administration may be provided by Highmark, Highmark Choice Company, Highmark Coverage Advantage, Highmark Health Insurance Company, First Priority Life Insurance Company, First Priority Health, Highmark Benefits Group, Highmark Select Resources, Highmark Senior Solutions Company or Highmark Senior Health Company, all of which are independent licensees of the Blue Cross and Blue Shield Association, an association of independent Blue Cross and Blue Shield plans.
Medical policies do not constitute medical advice, nor are they intended to govern the practice of medicine. They are intended to reflect reimbursement and coverage guidelines. Coverage for services may vary for individual members, based on the terms of the benefit contract.
Discrimination is Against the Law
The Claims Administrator/Insurer complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex. The Claims Administrator/Insurer does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. The Claims Administrator/ Insurer:
If you believe that the Claims Administrator/Insurer has failed to provide these services or discriminated in another way on the basis of race, color, national origin, age, disability, or sex, you can file a grievance with: Civil Rights Coordinator, P.O. Box 22492, Pittsburgh, PA 15222, Phone: 1-866-286-8295, TTY: 711, Fax: 412-544-2475, email: CivilRightsCoordinator@highmarkhealth.org. You can file a grievance in person or by mail, fax, or email. If you need help filing a grievance, the Civil Rights Coordinator is available to help you.
You can also file a civil rights complaint with the U.S. Department of Health and Human Services, Office for Civil Rights electronically through the Office for Civil Rights Complaint Portal, available at https://ocrportal.hhs.gov/ocr/portal/lobby.jsf, or by mail or phone at:
U.S. Department of Health and Human Services
200 Independence Avenue, SW
Room 509F, HHH Building
Washington, D.C. 20201
1-800-368-1019, 800-537-7697 (TDD)
Complaint forms are available at http://www.hhs.gov/ocr/office/file/index.html.